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Frequency: Quarterly
ISSN: 1553-6203 (Print)
ISSN: 1558-6340 (Online)
Case Report Open Access

Cryptococcal Meningoencephalitis in a Patient with Hyper IgM Syndrome Due to CD40 Deficiency: Case Report and Literature Review

Maram Al-Banyan1, Abdulhadi Alqahtani1, Farrukh Sheikh1, Agha M. Rehan Khaliq2, Hasan Al Rayes1, Ashraf Al-Tarifi1, Bandar Al-Saud1 and Rand K. Arnaout2
  • 1 King Faisal Specialist Hospital and Research Centre, Saudi Arabia
  • 2 Alfaisal University, Saudi Arabia

Abstract

Hyper-IgM syndrome (HIGM) due to CD40 deficiency is a very rare form of combined immunodeficiency with increased susceptibility to opportunistic infections. Cryptococcus is an opportunistic infection usually affecting immunocompromised individuals. This is the first report to describe a patient with HIGM due to CD40 deficiency presenting with meningoencephalitis secondary to Cryptococcus infection.

American Journal of Infectious Diseases
Volume 15 No. 1, 2019, 24-28

DOI: https://doi.org/10.3844/ajidsp.2019.24.28

Submitted On: 28 November 2018 Published On: 22 February 2019

How to Cite: Al-Banyan, M., Alqahtani, A., Sheikh, F., Khaliq, A. M. R., Al Rayes, H., Al-Tarifi, A., Al-Saud, B. & Arnaout, R. K. (2019). Cryptococcal Meningoencephalitis in a Patient with Hyper IgM Syndrome Due to CD40 Deficiency: Case Report and Literature Review. American Journal of Infectious Diseases, 15(1), 24-28. https://doi.org/10.3844/ajidsp.2019.24.28

Open AccessCopyright: © 2019 Maram Al-Banyan, Abdulhadi Alqahtani, Farrukh Sheikh, Agha M. Rehan Khaliq, Hasan Al Rayes, Ashraf Al-Tarifi, Bandar Al-Saud and Rand K. Arnaout. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Keywords

  • Hyper-IgM Syndrome
  • Cryptococcus Neoformans
  • Meningoencephalitis
  • Primary Immunodeficiency