OJBS Cover
Frequency: Quarterly
ISSN: 1608-4217 (Print)
ISSN: 2410-8561 (Online)
Research Article Open Access

Studying Interrelation of PDLIM4 with the Model of CD74-Mediated Development of Breast Cancer

Dmitry Sergeevich Kravchenko1, Yuriy Nikolaevich Lezhnin2, Anna Evgenyevna Ivanova1, Yulia Evgenyevna Kravchenko1 and Elena Ivanovna Frolova1
  • 1 Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences 16/10, Miklukho-Maklaya St., GSP-7, Moscow, 117997, Russia
  • 2 Engelhardt Institute of Molecular Biology, Russian Academy of Sciences 119991 Moscow, Russia

Abstract

Mammary gland tumors are often characterized by deregulation of RIL/PDLIM4 expression, however, PDLIM4-mediated mechanisms of cancer development still remain unknown. The aim of our research was to study the influence of PDLIM4-deregulation on transcript me changes of malignized cells. We performed а comparative NGS-analysis of breast cancer cell lines with suppressed and induced expression of PDLIM4 and identified a number of genes, whose expression correlated with PDLIM4 level. Among them we found CD74 gene, which is known as a potential marker of triple negative subtype of breast cancer. The obtained results allowed us to propose an interrelation between PDLIM4 and the CD74-mediated mechanism of breast cancer development and to analyze the correlation of PDLIM4 with the main components of CD-74-dependent model.

OnLine Journal of Biological Sciences
Volume 17 No. 2, 2017, 50-57

DOI: https://doi.org/10.3844/ojbsci.2017.50.57

Submitted On: 16 February 2017 Published On: 3 June 2017

How to Cite: Kravchenko, D. S., Lezhnin, Y. N., Ivanova, A. E., Kravchenko, Y. E. & Frolova, E. I. (2017). Studying Interrelation of PDLIM4 with the Model of CD74-Mediated Development of Breast Cancer. OnLine Journal of Biological Sciences, 17(2), 50-57. https://doi.org/10.3844/ojbsci.2017.50.57

Open AccessCopyright: © 2017 Dmitry Sergeevich Kravchenko, Yuriy Nikolaevich Lezhnin, Anna Evgenyevna Ivanova, Yulia Evgenyevna Kravchenko and Elena Ivanovna Frolova. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

  • 3,909 Views
  • 2,081 Downloads
  • 1 Citations

Download

Keywords

  • Breast Cancer
  • PDLIM4-Mediated Mechanisms
  • Malignized Cells